Drug interactions
Tiotropium-olodaterol + Voriconazole
Severity: Moderate
Tiotropium-olodaterol and Voriconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole can prolong the QT interval, and olodaterol may add tachycardia and hypokalemia. The combination may modestly increase risk of ventricular arrhythmias in susceptible patients.
What this interaction means in plain words
Tiotropium-olodaterol and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Tiotropium-olodaterol belongs to Respiratory; Voriconazole belongs to Anti Fungals.
Why it happens
Additive effects on cardiac repolarization and beta2-mediated hypokalemia.
What to do
Monitor ECG and correct potassium and magnesium abnormalities in patients with additional QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tiotropium-olodaterol
Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Frequently asked questions
Can I take Tiotropium-olodaterol with Voriconazole?
MediHelp rates the interaction as moderate. Tiotropium-olodaterol and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voriconazole can prolong the QT interval, and olodaterol may add tachycardia and hypokalemia. The combination may modestly increase risk of ventricular arrhythmias in susceptible patients.
How serious is the interaction between Tiotropium-olodaterol and Voriconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and correct potassium and magnesium abnormalities in patients with additional QT risk factors.
What other medicines interact with Tiotropium-olodaterol?
MediHelp also lists interactions of Tiotropium-olodaterol with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Tiotropium-olodaterol page.
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