Drug interactions
Tiotropium-olodaterol + Vorinostat
Severity: Moderate
Tiotropium-olodaterol and Vorinostat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vorinostat has been associated with QT prolongation, and olodaterol may add to this effect through beta2-agonist cardiac stimulation and potassium lowering. The combination may increase the risk of ventricular arrhythmias, especially with electrolyte disturbance.
What this interaction means in plain words
Tiotropium-olodaterol and Vorinostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Tiotropium-olodaterol belongs to Respiratory; Vorinostat belongs to Oncology.
Why it happens
Additive QT prolongation with beta2-agonist-related hypokalemia.
What to do
Obtain baseline and periodic ECG and monitor potassium and magnesium, correcting deficits promptly. Avoid adding further QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tiotropium-olodaterol
Other interactions of Vorinostat
- Thioridazine + Vorinostat Contraindicated
- Amiodarone + Vorinostat Major
- Amisulpride + Vorinostat Major
- Anagrelide + Vorinostat Major
- Asenapine + Vorinostat Major
- Chlorpromazine + Vorinostat Major
Frequently asked questions
Can I take Tiotropium-olodaterol with Vorinostat?
MediHelp rates the interaction as moderate. Tiotropium-olodaterol and Vorinostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vorinostat has been associated with QT prolongation, and olodaterol may add to this effect through beta2-agonist cardiac stimulation and potassium lowering. The combination may increase the risk of ventricular arrhythmias, especially with electrolyte disturbance.
How serious is the interaction between Tiotropium-olodaterol and Vorinostat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain baseline and periodic ECG and monitor potassium and magnesium, correcting deficits promptly. Avoid adding further QT-prolonging drugs.
What other medicines interact with Tiotropium-olodaterol?
MediHelp also lists interactions of Tiotropium-olodaterol with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Tiotropium-olodaterol page.
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