Drug interactions
Tipranavir + Tramadol
Severity: Moderate
Tipranavir and Tramadol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tipranavir, given with ritonavir, may raise tramadol exposure through CYP3A4 inhibition. Ritonavir also inhibits CYP2D6, which reduces formation of the active metabolite, so analgesia may be less reliable while parent-drug related adverse effects such as seizures and serotonin toxicity may increase.
What this interaction means in plain words
Tipranavir and Tramadol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Tipranavir belongs to Anti Virals; Tramadol belongs to Musculoskeletal.
Why it happens
Inhibition of CYP3A4 and CYP2D6 by ritonavir-boosted tipranavir alters tramadol metabolism.
What to do
Monitor for reduced analgesia, sedation, seizures and serotonin syndrome. Consider a non-tramadol analgesic if pain control is inadequate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tramadol
- Isocarboxazid + Tramadol Contraindicated
- Olanzapine / samidorphan + Tramadol Contraindicated
- Phenelzine + Tramadol Contraindicated
- Procarbazine + Tramadol Contraindicated
- Rasagiline + Tramadol Contraindicated
- Safinamide + Tramadol Contraindicated
Other interactions of Tipranavir
- Alfuzosin + Tipranavir Contraindicated
- Amiodarone + Tipranavir Contraindicated
- Atorvastatin + Tipranavir Contraindicated
- Avanafil + Tipranavir Contraindicated
- Cisapride + Tipranavir Contraindicated
- Colchicine + Tipranavir Contraindicated
Frequently asked questions
Can I take Tipranavir with Tramadol?
MediHelp rates the interaction as moderate. Tipranavir and Tramadol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tipranavir, given with ritonavir, may raise tramadol exposure through CYP3A4 inhibition. Ritonavir also inhibits CYP2D6, which reduces formation of the active metabolite, so analgesia may be less reliable while parent-drug related adverse effects such as seizures and serotonin toxicity may increase.
How serious is the interaction between Tipranavir and Tramadol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced analgesia, sedation, seizures and serotonin syndrome. Consider a non-tramadol analgesic if pain control is inadequate.
What other medicines interact with Tramadol?
MediHelp also lists interactions of Tramadol with, for example, Isocarboxazid, Olanzapine / samidorphan, Phenelzine. The full list is on the Tramadol page.
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