Drug interactions
Torsemide + Trazodone
Severity: Moderate
Torsemide and Trazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trazodone can occasionally cause hyponatremia, and a loop diuretic adds sodium loss, so the risk may be higher together. Trazodone also contributes orthostatic hypotension, which may be amplified by diuretic-related volume depletion.
What this interaction means in plain words
Torsemide and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Torsemide belongs to Cardiovascular; Trazodone belongs to Central Nervous System.
Why it happens
Diuretic-induced sodium loss combined with antidepressant-associated SIADH; additive orthostatic hypotension through alpha-blockade and volume depletion.
What to do
Monitor serum sodium and orthostatic blood pressure, especially in older adults, after initiation or dose changes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Torsemide
Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Frequently asked questions
Can I take Torsemide with Trazodone?
MediHelp rates the interaction as moderate. Torsemide and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trazodone can occasionally cause hyponatremia, and a loop diuretic adds sodium loss, so the risk may be higher together. Trazodone also contributes orthostatic hypotension, which may be amplified by diuretic-related volume depletion.
How serious is the interaction between Torsemide and Trazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum sodium and orthostatic blood pressure, especially in older adults, after initiation or dose changes.
What other medicines interact with Torsemide?
MediHelp also lists interactions of Torsemide with, for example, Amikacin, Amiodarone, Carbenoxolone. The full list is on the Torsemide page.
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