Drug interactions
Tramadol + Zolmitriptan
Severity: Moderate
Tramadol and Zolmitriptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have serotonergic activity, so the combination carries a risk of serotonin syndrome, although reports are uncommon. Tramadol can also lower the seizure threshold.
What this interaction means in plain words
Tramadol and Zolmitriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Tramadol belongs to Musculoskeletal; Zolmitriptan belongs to Central Nervous System.
Why it happens
Additive serotonergic effects via 5-HT1B/1D agonism and tramadol's serotonin reuptake inhibition.
What to do
Monitor for agitation, tremor, hyperreflexia and autonomic instability, particularly when doses are raised. Stop and treat if serotonin syndrome is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tramadol
- Isocarboxazid + Tramadol Contraindicated
- Olanzapine / samidorphan + Tramadol Contraindicated
- Phenelzine + Tramadol Contraindicated
- Procarbazine + Tramadol Contraindicated
- Rasagiline + Tramadol Contraindicated
- Safinamide + Tramadol Contraindicated
Other interactions of Zolmitriptan
- Almotriptan + Zolmitriptan Contraindicated
- Dihydroergotamine intranasal + Zolmitriptan Contraindicated
- Dihydroergotamine + Zolmitriptan Contraindicated
- Eletriptan + Zolmitriptan Contraindicated
- Ergoloid mesylates + Zolmitriptan Contraindicated
- Ergotamine + Zolmitriptan Contraindicated
Frequently asked questions
Can I take Tramadol with Zolmitriptan?
MediHelp rates the interaction as moderate. Tramadol and Zolmitriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have serotonergic activity, so the combination carries a risk of serotonin syndrome, although reports are uncommon. Tramadol can also lower the seizure threshold.
How serious is the interaction between Tramadol and Zolmitriptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for agitation, tremor, hyperreflexia and autonomic instability, particularly when doses are raised. Stop and treat if serotonin syndrome is suspected.
What other medicines interact with Tramadol?
MediHelp also lists interactions of Tramadol with, for example, Isocarboxazid, Olanzapine / samidorphan, Phenelzine. The full list is on the Tramadol page.
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