Drug interactions
Trastuzumab deruxtecan + Vedolizumab
Severity: Moderate
Trastuzumab deruxtecan and Vedolizumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trastuzumab deruxtecan commonly causes neutropenia, and vedolizumab alters gut immune defence. Together infection risk may increase, though vedolizumab's systemic effect is limited.
What this interaction means in plain words
Trastuzumab deruxtecan and Vedolizumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Trastuzumab deruxtecan belongs to Oncology; Vedolizumab belongs to Gastrointestinal Tract.
Why it happens
Additive myelosuppression and gut-selective immunosuppression.
What to do
Monitor blood counts and for infections, including gastrointestinal infections. Manage neutropenia per oncology protocols.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vedolizumab
- Natalizumab + Vedolizumab Contraindicated
- Baricitinib + Vedolizumab Major
- Certolizumab pegol + Vedolizumab Major
- Etanercept + Vedolizumab Major
- Golimumab + Vedolizumab Major
- Smallpox vaccine live + Vedolizumab Major
Other interactions of Trastuzumab deruxtecan
Frequently asked questions
Can I take Trastuzumab deruxtecan with Vedolizumab?
MediHelp rates the interaction as moderate. Trastuzumab deruxtecan and Vedolizumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trastuzumab deruxtecan commonly causes neutropenia, and vedolizumab alters gut immune defence. Together infection risk may increase, though vedolizumab's systemic effect is limited.
How serious is the interaction between Trastuzumab deruxtecan and Vedolizumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and for infections, including gastrointestinal infections. Manage neutropenia per oncology protocols.
What other medicines interact with Vedolizumab?
MediHelp also lists interactions of Vedolizumab with, for example, Natalizumab, Baricitinib, Certolizumab pegol. The full list is on the Vedolizumab page.
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