Drug interactions
Trazodone + Voriconazole
Severity: Moderate
Trazodone and Voriconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trazodone is metabolized to its active metabolite mainly by CYP3A4, and voriconazole strongly inhibits this enzyme. Higher trazodone levels can cause excess sedation, orthostatic hypotension and QT prolongation, and voriconazole itself can prolong the QT interval.
What this interaction means in plain words
Trazodone and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Trazodone belongs to Central Nervous System; Voriconazole belongs to Anti Fungals.
Why it happens
Voriconazole inhibits CYP3A4 metabolism of trazodone, with additive QT effects.
What to do
Start with a lower trazodone dose and titrate by response, watching for sedation and hypotension. Check an ECG if there are other QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Frequently asked questions
Can I take Trazodone with Voriconazole?
MediHelp rates the interaction as moderate. Trazodone and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trazodone is metabolized to its active metabolite mainly by CYP3A4, and voriconazole strongly inhibits this enzyme. Higher trazodone levels can cause excess sedation, orthostatic hypotension and QT prolongation, and voriconazole itself can prolong the QT interval.
How serious is the interaction between Trazodone and Voriconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with a lower trazodone dose and titrate by response, watching for sedation and hypotension. Check an ECG if there are other QT risk factors.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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