Drug interactions
Trazodone + Ziconotide
Severity: Moderate
Trazodone and Ziconotide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ziconotide, given intrathecally, can cause sedation, dizziness and cognitive impairment, and trazodone adds to CNS depression. Psychiatric and neurological adverse effects of ziconotide may be harder to assess with other CNS-active drugs.
What this interaction means in plain words
Trazodone and Ziconotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Trazodone belongs to Central Nervous System; Ziconotide belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects.
What to do
Monitor mental status and level of consciousness, and reduce trazodone if oversedation occurs. Stop or lower ziconotide if cognitive or psychiatric symptoms emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Other interactions of Ziconotide
- Clozapine + Ziconotide Major
- Alprazolam + Ziconotide Moderate
- Amitriptyline + Ziconotide Moderate
- Amobarbital + Ziconotide Moderate
- Aripiprazole + Ziconotide Moderate
- Armodafinil + Ziconotide Moderate
Frequently asked questions
Can I take Trazodone with Ziconotide?
MediHelp rates the interaction as moderate. Trazodone and Ziconotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ziconotide, given intrathecally, can cause sedation, dizziness and cognitive impairment, and trazodone adds to CNS depression. Psychiatric and neurological adverse effects of ziconotide may be harder to assess with other CNS-active drugs.
How serious is the interaction between Trazodone and Ziconotide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor mental status and level of consciousness, and reduce trazodone if oversedation occurs. Stop or lower ziconotide if cognitive or psychiatric symptoms emerge.
What other medicines interact with Trazodone?
MediHelp also lists interactions of Trazodone with, for example, Arsenic trioxide, Ibutilide, Isocarboxazid. The full list is on the Trazodone page.
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