Drug interactions
Triclabendazole + Voriconazole
Severity: Major
Triclabendazole and Voriconazole: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Triclabendazole and its metabolites may prolong the QT interval and inhibit CYP2C19, which could raise voriconazole levels. Together this may increase the risk of QT-related arrhythmia and voriconazole toxicity.
What this interaction means in plain words
Triclabendazole and Voriconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Triclabendazole belongs to Anti Parasitic; Voriconazole belongs to Anti Fungals.
Why it happens
Additive QT prolongation, plus possible CYP2C19 inhibition by triclabendazole reducing voriconazole clearance.
What to do
Obtain baseline ECG and correct electrolyte disturbances before use. Monitor ECG and consider voriconazole level monitoring; avoid if other QT risk factors are present.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Other interactions of Triclabendazole
Frequently asked questions
Can I take Triclabendazole with Voriconazole?
MediHelp rates the interaction as major. Triclabendazole and Voriconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Triclabendazole and its metabolites may prolong the QT interval and inhibit CYP2C19, which could raise voriconazole levels. Together this may increase the risk of QT-related arrhythmia and voriconazole toxicity.
How serious is the interaction between Triclabendazole and Voriconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain baseline ECG and correct electrolyte disturbances before use. Monitor ECG and consider voriconazole level monitoring; avoid if other QT risk factors are present.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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