Drug interactions
Trimethoprim + Trimipramine
Severity: Moderate
Trimethoprim and Trimipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trimethoprim has been associated with QT prolongation in some reports, and tricyclics can also prolong QT. Combined use may add to arrhythmia risk in susceptible patients, though evidence is limited.
What this interaction means in plain words
Trimethoprim and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Trimethoprim belongs to Anti Bacterial; Trimipramine belongs to Central Nervous System.
Why it happens
Possible additive QT prolongation; trimethoprim's effect is not firmly established.
What to do
Check ECG and potassium in patients with cardiac disease or other QT-prolonging drugs. Consider an alternative anti-infective if the QTc is prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Other interactions of Trimethoprim
Frequently asked questions
Can I take Trimethoprim with Trimipramine?
MediHelp rates the interaction as moderate. Trimethoprim and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trimethoprim has been associated with QT prolongation in some reports, and tricyclics can also prolong QT. Combined use may add to arrhythmia risk in susceptible patients, though evidence is limited.
How serious is the interaction between Trimethoprim and Trimipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG and potassium in patients with cardiac disease or other QT-prolonging drugs. Consider an alternative anti-infective if the QTc is prolonged.
What other medicines interact with Trimipramine?
MediHelp also lists interactions of Trimipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Trimipramine page.
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