Drug interactions
Tucatinib + Umeclidinium-vilanterol
Severity: Moderate
Tucatinib and Umeclidinium-vilanterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tucatinib is a CYP3A4 inhibitor and can increase vilanterol exposure, although systemic vilanterol levels from inhalation are low. Higher levels may increase tachycardia, tremor and hypokalemia.
What this interaction means in plain words
Tucatinib and Umeclidinium-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Tucatinib belongs to Oncology; Umeclidinium-vilanterol belongs to Respiratory.
Why it happens
Inhibition of CYP3A4-mediated metabolism of vilanterol.
What to do
Monitor heart rate, tremor and potassium for beta-agonist adverse effects. Reduce or review the beta-agonist if symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Umeclidinium-vilanterol
Other interactions of Tucatinib
- Cisapride + Tucatinib Contraindicated
- Eletriptan + Tucatinib Contraindicated
- Ergotamine + Tucatinib Contraindicated
- Flibanserin + Tucatinib Contraindicated
- Ranolazine + Tucatinib Contraindicated
- Amobarbital + Tucatinib Major
Frequently asked questions
Can I take Tucatinib with Umeclidinium-vilanterol?
MediHelp rates the interaction as moderate. Tucatinib and Umeclidinium-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tucatinib is a CYP3A4 inhibitor and can increase vilanterol exposure, although systemic vilanterol levels from inhalation are low. Higher levels may increase tachycardia, tremor and hypokalemia.
How serious is the interaction between Tucatinib and Umeclidinium-vilanterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, tremor and potassium for beta-agonist adverse effects. Reduce or review the beta-agonist if symptoms occur.
What other medicines interact with Umeclidinium-vilanterol?
MediHelp also lists interactions of Umeclidinium-vilanterol with, for example, Aclidinium, Amiodarone, Amitriptyline. The full list is on the Umeclidinium-vilanterol page.
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