Drug interactions
Valbenazine + Voriconazole
Severity: Major
Valbenazine and Voriconazole: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole raises exposure to valbenazine's active metabolite through CYP3A4 inhibition, and both agents can prolong the QT interval. This increases the risk of somnolence and QT-related arrhythmia.
What this interaction means in plain words
Valbenazine and Voriconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Valbenazine belongs to Central Nervous System; Voriconazole belongs to Anti Fungals.
Why it happens
CYP3A4 inhibition increases valbenazine exposure, with additive QT prolongation.
What to do
Reduce valbenazine to 40 mg daily during voriconazole use per labeling. Monitor ECG and electrolytes, especially with other QT risk factors.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Other interactions of Valbenazine
- Deutetrabenazine + Valbenazine Contraindicated
- Tranylcypromine + Valbenazine Contraindicated
- Amiodarone + Valbenazine Major
- Amisulpride + Valbenazine Major
- Apalutamide + Valbenazine Major
- Carbamazepine + Valbenazine Major
Frequently asked questions
Can I take Valbenazine with Voriconazole?
MediHelp rates the interaction as major. Valbenazine and Voriconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Voriconazole raises exposure to valbenazine's active metabolite through CYP3A4 inhibition, and both agents can prolong the QT interval. This increases the risk of somnolence and QT-related arrhythmia.
How serious is the interaction between Valbenazine and Voriconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce valbenazine to 40 mg daily during voriconazole use per labeling. Monitor ECG and electrolytes, especially with other QT risk factors.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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