Drug interactions
Vilazodone + Warfarin
Severity: Moderate
Vilazodone and Warfarin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vilazodone is a serotonin reuptake inhibitor and partial 5-HT1A agonist whose labeling warns of increased bleeding with anticoagulants. The combination may raise bleeding risk.
What this interaction means in plain words
Vilazodone and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Vilazodone belongs to Central Nervous System; Warfarin belongs to Cardiovascular.
Why it happens
Impaired platelet serotonin uptake and aggregation adds to warfarin anticoagulation.
What to do
Monitor INR and bleeding signs when starting or stopping vilazodone.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Warfarin
- Defibrotide + Warfarin Contraindicated
- Ketorolac + Warfarin Contraindicated
- Abciximab + Warfarin Major
- Acetylsalicylic acid + Warfarin Major
- Adagrasib + Warfarin Major
- Amiodarone + Warfarin Major
Other interactions of Vilazodone
- Isocarboxazid + Vilazodone Contraindicated
- Methylene blue + Vilazodone Contraindicated
- Phenelzine + Vilazodone Contraindicated
- Rasagiline + Vilazodone Contraindicated
- Selegiline transdermal + Vilazodone Contraindicated
- Selegiline + Vilazodone Contraindicated
Frequently asked questions
Can I take Vilazodone with Warfarin?
MediHelp rates the interaction as moderate. Vilazodone and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vilazodone is a serotonin reuptake inhibitor and partial 5-HT1A agonist whose labeling warns of increased bleeding with anticoagulants. The combination may raise bleeding risk.
How serious is the interaction between Vilazodone and Warfarin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor INR and bleeding signs when starting or stopping vilazodone.
What other medicines interact with Warfarin?
MediHelp also lists interactions of Warfarin with, for example, Defibrotide, Ketorolac, Abciximab. The full list is on the Warfarin page.
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