Drug interactions
Vilazodone + Zafirlukast
Severity: Minor
Vilazodone and Zafirlukast: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vilazodone is a mild CYP3A4 inhibitor and is not expected to alter zafirlukast exposure meaningfully. Zafirlukast is mainly cleared by CYP2C9 with some CYP3A4 involvement, so any effect is likely trivial.
What this interaction means in plain words
Vilazodone and Zafirlukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Vilazodone belongs to Central Nervous System; Zafirlukast belongs to Respiratory.
Why it happens
Possible weak CYP3A4 inhibition by vilazodone slightly reducing zafirlukast metabolism; not established as clinically relevant.
What to do
No dose adjustment is needed. Monitor for zafirlukast adverse effects such as headache or gastrointestinal upset.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Zafirlukast
- Pimozide + Zafirlukast Contraindicated
- Lomitapide + Zafirlukast Major
- Nilotinib + Zafirlukast Major
- Warfarin + Zafirlukast Major
- Apalutamide + Zafirlukast Moderate
- Carbamazepine + Zafirlukast Moderate
Other interactions of Vilazodone
- Isocarboxazid + Vilazodone Contraindicated
- Methylene blue + Vilazodone Contraindicated
- Phenelzine + Vilazodone Contraindicated
- Rasagiline + Vilazodone Contraindicated
- Selegiline transdermal + Vilazodone Contraindicated
- Selegiline + Vilazodone Contraindicated
Frequently asked questions
Can I take Vilazodone with Zafirlukast?
MediHelp rates the interaction as minor. Vilazodone and Zafirlukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Vilazodone is a mild CYP3A4 inhibitor and is not expected to alter zafirlukast exposure meaningfully. Zafirlukast is mainly cleared by CYP2C9 with some CYP3A4 involvement, so any effect is likely trivial.
How serious is the interaction between Vilazodone and Zafirlukast?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. Monitor for zafirlukast adverse effects such as headache or gastrointestinal upset.
What other medicines interact with Zafirlukast?
MediHelp also lists interactions of Zafirlukast with, for example, Pimozide, Lomitapide, Nilotinib. The full list is on the Zafirlukast page.
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