Drug interactions
Vilazodone + Ziprasidone
Severity: Moderate
Vilazodone and Ziprasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a serotonergic antidepressant with ziprasidone may increase the risk of serotonin syndrome or neuroleptic malignant syndrome. Ziprasidone also prolongs the QT interval, which adds a separate cardiac concern in vulnerable patients.
What this interaction means in plain words
Vilazodone and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Vilazodone belongs to Central Nervous System; Ziprasidone belongs to Central Nervous System.
Why it happens
Additive serotonergic and dopamine-blocking effects; ziprasidone also independently prolongs QT.
What to do
Monitor for signs of serotonin toxicity and neuroleptic malignant syndrome, and check electrolytes and ECG in patients with QT risk factors. Stop therapy if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vilazodone
- Isocarboxazid + Vilazodone Contraindicated
- Methylene blue + Vilazodone Contraindicated
- Phenelzine + Vilazodone Contraindicated
- Rasagiline + Vilazodone Contraindicated
- Selegiline transdermal + Vilazodone Contraindicated
- Selegiline + Vilazodone Contraindicated
Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Frequently asked questions
Can I take Vilazodone with Ziprasidone?
MediHelp rates the interaction as moderate. Vilazodone and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining a serotonergic antidepressant with ziprasidone may increase the risk of serotonin syndrome or neuroleptic malignant syndrome. Ziprasidone also prolongs the QT interval, which adds a separate cardiac concern in vulnerable patients.
How serious is the interaction between Vilazodone and Ziprasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of serotonin toxicity and neuroleptic malignant syndrome, and check electrolytes and ECG in patients with QT risk factors. Stop therapy if toxicity develops.
What other medicines interact with Vilazodone?
MediHelp also lists interactions of Vilazodone with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Vilazodone page.
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