Drug interactions
Voclosporin + Zoledronic acid
Severity: Moderate
Voclosporin and Zoledronic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both zoledronic acid and voclosporin can impair kidney function. Used together they may increase the risk of acute kidney injury or a decline in renal function, especially in patients with existing renal impairment such as lupus nephritis.
What this interaction means in plain words
Voclosporin and Zoledronic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Voclosporin belongs to Miscellaneous; Zoledronic acid belongs to Musculoskeletal.
Why it happens
Additive nephrotoxicity: calcineurin inhibitor-induced renal vasoconstriction combined with direct renal tubular toxicity of intravenous bisphosphonate.
What to do
Check serum creatinine and eGFR before each zoledronic acid dose and ensure adequate hydration. Monitor renal function after infusion and adjust or withhold treatment if function deteriorates.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Zoledronic acid
- Amikacin + Zoledronic acid Moderate
- Bumetanide + Zoledronic acid Moderate
- Dichlorphenamide + Zoledronic acid Moderate
- Ethacrynic acid + Zoledronic acid Moderate
- Foscarnet + Zoledronic acid Moderate
- Gentamicin + Zoledronic acid Moderate
Other interactions of Voclosporin
- Clarithromycin + Voclosporin Contraindicated
- Cyclosporin + Voclosporin Contraindicated
- Ensitrelvir + Voclosporin Contraindicated
- Itraconazole + Voclosporin Contraindicated
- Ketoconazole + Voclosporin Contraindicated
- Posaconazole + Voclosporin Contraindicated
Frequently asked questions
Can I take Voclosporin with Zoledronic acid?
MediHelp rates the interaction as moderate. Voclosporin and Zoledronic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both zoledronic acid and voclosporin can impair kidney function. Used together they may increase the risk of acute kidney injury or a decline in renal function, especially in patients with existing renal impairment such as lupus nephritis.
How serious is the interaction between Voclosporin and Zoledronic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum creatinine and eGFR before each zoledronic acid dose and ensure adequate hydration. Monitor renal function after infusion and adjust or withhold treatment if function deteriorates.
What other medicines interact with Zoledronic acid?
MediHelp also lists interactions of Zoledronic acid with, for example, Amikacin, Bumetanide, Dichlorphenamide. The full list is on the Zoledronic acid page.
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