Drug interactions
Voriconazole + Zonisamide
Severity: Minor
Voriconazole and Zonisamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole may increase zonisamide levels, which could cause drowsiness, dizziness, cognitive slowing or other dose-related adverse effects. Zonisamide is metabolised partly by CYP3A4, so the effect is probably modest.
What this interaction means in plain words
Voriconazole and Zonisamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Voriconazole belongs to Anti Fungals; Zonisamide belongs to Central Nervous System.
Why it happens
Voriconazole inhibits CYP3A4, a metabolic pathway of zonisamide.
What to do
No empirical dose change is needed. Monitor for CNS adverse effects and adjust the zonisamide dose if they occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Other interactions of Zonisamide
- Zonisamide + Zuranolone Major
- Acetazolamide + Zonisamide Moderate
- Amisulpride + Zonisamide Moderate
- Amobarbital + Zonisamide Moderate
- Apalutamide + Zonisamide Moderate
- Asenapine transdermal + Zonisamide Moderate
Frequently asked questions
Can I take Voriconazole with Zonisamide?
MediHelp rates the interaction as minor. Voriconazole and Zonisamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Voriconazole may increase zonisamide levels, which could cause drowsiness, dizziness, cognitive slowing or other dose-related adverse effects. Zonisamide is metabolised partly by CYP3A4, so the effect is probably modest.
How serious is the interaction between Voriconazole and Zonisamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change is needed. Monitor for CNS adverse effects and adjust the zonisamide dose if they occur.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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