Interactions médicamenteuses
Cyclobenzaprine + Glycopyrrolate
Gravité: Modérée
Cyclobenzaprine and Glycopyrrolate: moderate interaction.
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Résumé
Both drugs have antimuscarinic activity, so combining them increases anticholinergic effects such as dry mouth, constipation, urinary retention, blurred vision and tachycardia. Older adults and patients with glaucoma, prostatic hypertrophy or ileus are at greatest risk.
Ce que signifie cette interaction, en termes simples
Cyclobenzaprine and Glycopyrrolate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclobenzaprine belongs to Musculoskeletal; Glycopyrrolate belongs to Respiratory.
Pourquoi elle survient
Additive blockade of muscarinic receptors by cyclobenzaprine and glycopyrrolate.
Conduite à tenir
Monitor for anticholinergic adverse effects such as urinary retention, constipation and confusion, and reduce the dose or choose an alternative if they emerge. Avoid in patients with narrow-angle glaucoma or obstructive uropathy.
Questions à poser à votre pharmacien
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Autres interactions de Cyclobenzaprine
- Cyclobenzaprine + Isocarboxazid Contre-indiquée
- Cyclobenzaprine + Linezolid Contre-indiquée
- Cyclobenzaprine + Phenelzine Contre-indiquée
- Cyclobenzaprine + Safinamide Contre-indiquée
- Cyclobenzaprine + Selegiline Contre-indiquée
- Cyclobenzaprine + Selegiline transdermal Contre-indiquée
Autres interactions de Glycopyrrolate
- Glycopyrrolate + Potassium chloride Majeure
- Amitriptyline + Glycopyrrolate Modérée
- Atropine + Glycopyrrolate Modérée
- Bethanechol + Glycopyrrolate Modérée
- Chlorpromazine + Glycopyrrolate Modérée
- Clomipramine + Glycopyrrolate Modérée
Questions fréquentes
Can I take Cyclobenzaprine with Glycopyrrolate?
MediHelp rates the interaction as moderate. Cyclobenzaprine and Glycopyrrolate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have antimuscarinic activity, so combining them increases anticholinergic effects such as dry mouth, constipation, urinary retention, blurred vision and tachycardia. Older adults and patients with glaucoma, prostatic hypertrophy or ileus are at greatest risk.
How serious is the interaction between Cyclobenzaprine and Glycopyrrolate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic adverse effects such as urinary retention, constipation and confusion, and reduce the dose or choose an alternative if they emerge. Avoid in patients with narrow-angle glaucoma or obstructive uropathy.
What other medicines interact with Cyclobenzaprine?
MediHelp also lists interactions of Cyclobenzaprine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Cyclobenzaprine page.
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