Interactions médicamenteuses
Cobicistat + Flutamide
Gravité: Modérée
Cobicistat and Flutamide: moderate interaction.
Dernière mise à jour
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Résumé
Cobicistat is a strong CYP3A4 inhibitor and may raise flutamide exposure, although flutamide is mainly cleared by CYP1A2. Higher levels of flutamide or its metabolites could increase the risk of hepatotoxicity.
Ce que signifie cette interaction, en termes simples
Cobicistat and Flutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cobicistat belongs to Miscellaneous; Flutamide belongs to Endocrine.
Pourquoi elle survient
Cobicistat inhibits CYP3A4, reducing metabolism of flutamide and its metabolites.
Conduite à tenir
Monitor liver enzymes closely and counsel patients on symptoms of liver injury. Consider an alternative antiandrogen or antiretroviral if abnormalities arise.
Questions à poser à votre pharmacien
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Autres interactions de Flutamide
- Flutamide + Idelalisib Majeure
- Flutamide + Levoketoconazole Majeure
- Flutamide + Pexidartinib Majeure
- Flutamide + Pretomanid Majeure
- Flutamide + Valoctocogene roxaparvovec Majeure
- Apalutamide + Flutamide Modérée
Autres interactions de Cobicistat
- Alfuzosin + Cobicistat Contre-indiquée
- Apalutamide + Cobicistat Contre-indiquée
- Cobicistat + Colchicine Contre-indiquée
- Cobicistat + Dronedarone Contre-indiquée
- Cobicistat + Eletriptan Contre-indiquée
- Cobicistat + Eplerenone Contre-indiquée
Questions fréquentes
Can I take Cobicistat with Flutamide?
MediHelp rates the interaction as moderate. Cobicistat and Flutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cobicistat is a strong CYP3A4 inhibitor and may raise flutamide exposure, although flutamide is mainly cleared by CYP1A2. Higher levels of flutamide or its metabolites could increase the risk of hepatotoxicity.
How serious is the interaction between Cobicistat and Flutamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes closely and counsel patients on symptoms of liver injury. Consider an alternative antiandrogen or antiretroviral if abnormalities arise.
What other medicines interact with Flutamide?
MediHelp also lists interactions of Flutamide with, for example, Idelalisib, Levoketoconazole, Pexidartinib. The full list is on the Flutamide page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
