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Interactions médicamenteuses

Dexmethylphenidate + Isocarboxazid

Gravité: Contre-indiquée

Dexmethylphenidate and Isocarboxazid: contraindicated interaction.

Dernière mise à jour

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Résumé

Dexmethylphenidate with an MAOI can precipitate hypertensive crisis. Labeling prohibits use during or within 14 days of MAOI therapy.

Ce que signifie cette interaction, en termes simples

Dexmethylphenidate and Isocarboxazid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Dexmethylphenidate belongs to Central Nervous System; Isocarboxazid belongs to Central Nervous System.

Niveau de preuve: High

Pourquoi elle survient

MAO inhibition combined with stimulant-induced catecholamine release and reuptake blockade produces excessive adrenergic stimulation.

Conduite à tenir

Avoid the combination and allow 14 days after stopping the MAOI before dexmethylphenidate. Consider a non-stimulant ADHD agent only after appropriate washout.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Dexmethylphenidate with Isocarboxazid?

MediHelp rates the interaction as contraindicated. Dexmethylphenidate and Isocarboxazid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Dexmethylphenidate with an MAOI can precipitate hypertensive crisis. Labeling prohibits use during or within 14 days of MAOI therapy.

How serious is the interaction between Dexmethylphenidate and Isocarboxazid?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and allow 14 days after stopping the MAOI before dexmethylphenidate. Consider a non-stimulant ADHD agent only after appropriate washout.

What other medicines interact with Isocarboxazid?

MediHelp also lists interactions of Isocarboxazid with, for example, 5-HTP, Amitriptyline, Amobarbital. The full list is on the Isocarboxazid page.

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