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Interactions médicamenteuses

Dexmethylphenidate + Linezolid

Gravité: Contre-indiquée

Dexmethylphenidate and Linezolid: contraindicated interaction.

Dernière mise à jour

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Résumé

Dexmethylphenidate increases synaptic norepinephrine and dopamine, and linezolid blocks their breakdown. This can provoke hypertensive crisis.

Ce que signifie cette interaction, en termes simples

Dexmethylphenidate and Linezolid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Dexmethylphenidate belongs to Central Nervous System; Linezolid belongs to Anti Bacterial.

Niveau de preuve: Moderate

Pourquoi elle survient

MAO inhibition by linezolid potentiates catecholamines released or retained by dexmethylphenidate.

Conduite à tenir

Avoid combination and do not give dexmethylphenidate during or within 14 days of an MAOI. If linezolid is essential, hold the stimulant and monitor blood pressure.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Dexmethylphenidate with Linezolid?

MediHelp rates the interaction as contraindicated. Dexmethylphenidate and Linezolid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Dexmethylphenidate increases synaptic norepinephrine and dopamine, and linezolid blocks their breakdown. This can provoke hypertensive crisis.

How serious is the interaction between Dexmethylphenidate and Linezolid?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combination and do not give dexmethylphenidate during or within 14 days of an MAOI. If linezolid is essential, hold the stimulant and monitor blood pressure.

What other medicines interact with Linezolid?

MediHelp also lists interactions of Linezolid with, for example, Amoxapine, Atomoxetine, Benzphetamine. The full list is on the Linezolid page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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