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Interactions médicamenteuses

Diflunisal + Prasugrel

Gravité: Majeure

Diflunisal and Prasugrel: major interaction.

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Résumé

Combining an NSAID with a potent antiplatelet increases the risk of bleeding, particularly gastrointestinal. The risk is higher with chronic NSAID use.

Ce que signifie cette interaction, en termes simples

Diflunisal and Prasugrel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Diflunisal belongs to Musculoskeletal; Prasugrel belongs to Cardiovascular.

Niveau de preuve: Moderate

Pourquoi elle survient

Additive platelet inhibition (P2Y12 blockade plus COX-1 inhibition) and NSAID gastric mucosal injury.

Conduite à tenir

Avoid chronic NSAID use with prasugrel where possible and use paracetamol. If necessary, add gastroprotection and monitor for bleeding.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Diflunisal with Prasugrel?

MediHelp rates the interaction as major. Diflunisal and Prasugrel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining an NSAID with a potent antiplatelet increases the risk of bleeding, particularly gastrointestinal. The risk is higher with chronic NSAID use.

How serious is the interaction between Diflunisal and Prasugrel?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid chronic NSAID use with prasugrel where possible and use paracetamol. If necessary, add gastroprotection and monitor for bleeding.

What other medicines interact with Diflunisal?

MediHelp also lists interactions of Diflunisal with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Diflunisal page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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