Interazioni tra farmaci
Riociguat + Vardenafil
Gravità: Controindicata
Riociguat and Vardenafil: contraindicated interaction.
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Sintesi
Riociguat stimulates soluble guanylate cyclase and vardenafil prevents cGMP degradation, which together produce severe additive hypotension. Labeling prohibits PDE5 inhibitors with riociguat.
Cosa significa questa interazione in parole semplici
Riociguat and Vardenafil are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Riociguat belongs to Cardiovascular; Vardenafil belongs to Genitourinary.
Perché avviene
Increased cGMP synthesis plus reduced cGMP breakdown cause additive vasodilation.
Cosa fare
Do not combine. Use a different treatment for erectile dysfunction in patients on riociguat.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Vardenafil
- Amyl nitrite + Vardenafil Controindicata
- Glyceryl trinitrate pr + Vardenafil Controindicata
- Isosorbide dinitrate + Vardenafil Controindicata
- Isosorbide mononitrate + Vardenafil Controindicata
- Nicorandil + Vardenafil Controindicata
- Nitroglycerin po + Vardenafil Controindicata
Altre interazioni di Riociguat
- Avanafil + Riociguat Controindicata
- Dipyridamole + Riociguat Controindicata
- Isosorbide dinitrate + Riociguat Controindicata
- Isosorbide mononitrate + Riociguat Controindicata
- Nitroglycerin + Riociguat Controindicata
- Riociguat + Sildenafil Controindicata
Domande frequenti
Can I take Riociguat with Vardenafil?
MediHelp rates the interaction as contraindicated. Riociguat and Vardenafil are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Riociguat stimulates soluble guanylate cyclase and vardenafil prevents cGMP degradation, which together produce severe additive hypotension. Labeling prohibits PDE5 inhibitors with riociguat.
How serious is the interaction between Riociguat and Vardenafil?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine. Use a different treatment for erectile dysfunction in patients on riociguat.
What other medicines interact with Vardenafil?
MediHelp also lists interactions of Vardenafil with, for example, Amyl nitrite, Glyceryl trinitrate pr, Isosorbide dinitrate. The full list is on the Vardenafil page.
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