相互作用
Fluvastatin + Niacin
重症度: 中等度
Fluvastatin and Niacin: moderate interaction.
最終更新日
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概要
Lipid-modifying doses of niacin given with a statin may add to the risk of myopathy and rarely rhabdomyolysis. The risk appears greatest at high niacin doses and in patients with renal impairment or advanced age.
この相互作用をわかりやすく説明すると
Fluvastatin and Niacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluvastatin belongs to Cardiovascular; Niacin belongs to Cardiovascular.
なぜ起こるのか
Additive myotoxicity; niacin may also contribute to muscle injury through an unclear mechanism.
対処法
Use the lowest effective doses and educate the patient to report muscle pain, weakness or dark urine. Check CK and renal function if symptoms develop.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、FluvastatinとNiacinの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Fluvastatinのその他の相互作用
Niacinのその他の相互作用
よくある質問
Can I take Fluvastatin with Niacin?
MediHelp rates the interaction as moderate. Fluvastatin and Niacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lipid-modifying doses of niacin given with a statin may add to the risk of myopathy and rarely rhabdomyolysis. The risk appears greatest at high niacin doses and in patients with renal impairment or advanced age.
How serious is the interaction between Fluvastatin and Niacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and educate the patient to report muscle pain, weakness or dark urine. Check CK and renal function if symptoms develop.
What other medicines interact with Fluvastatin?
MediHelp also lists interactions of Fluvastatin with, for example, Cyclosporine, Cyclosporin, Gemfibrozil. The full list is on the Fluvastatin page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
