Interações medicamentosas
Cefotaxime + Streptomycin
Gravidade: Moderada
Cefotaxime and Streptomycin: moderate interaction.
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Resumo
Combining a cephalosporin with an aminoglycoside may raise the risk of kidney injury, and aminoglycosides carry their own risk of hearing and vestibular damage. The additive risk with cefotaxime is modest and mainly reported in patients with other risk factors such as renal impairment, advanced age or dehydration.
O que esta interação significa em palavras simples
Cefotaxime and Streptomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cefotaxime belongs to Anti Bacterial; Streptomycin belongs to Anti Bacterial.
Por que acontece
Possible additive nephrotoxicity, with aminoglycoside-related renal tubular injury potentially worsening renal clearance and thus ototoxic exposure.
O que fazer
Monitor serum creatinine and urine output regularly and keep the patient well hydrated. Monitor streptomycin levels where available and assess hearing and vestibular function during prolonged courses.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Cefotaxime
- Cefotaxime + Typhoid vaccine live Grave
- Amikacin + Cefotaxime Moderada
- Cefotaxime + Cholera vaccine Moderada
- Cefotaxime + Dexamethasone-tobramycin Moderada
- Cefotaxime + Gentamicin Moderada
- Cefotaxime + Kanamycin Moderada
Outras interações de Streptomycin
Perguntas frequentes
Can I take Cefotaxime with Streptomycin?
MediHelp rates the interaction as moderate. Cefotaxime and Streptomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining a cephalosporin with an aminoglycoside may raise the risk of kidney injury, and aminoglycosides carry their own risk of hearing and vestibular damage. The additive risk with cefotaxime is modest and mainly reported in patients with other risk factors such as renal impairment, advanced age or dehydration.
How serious is the interaction between Cefotaxime and Streptomycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and urine output regularly and keep the patient well hydrated. Monitor streptomycin levels where available and assess hearing and vestibular function during prolonged courses.
What other medicines interact with Cefotaxime?
MediHelp also lists interactions of Cefotaxime with, for example, Typhoid vaccine live, Amikacin, Cholera vaccine. The full list is on the Cefotaxime page.
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