Interações medicamentosas
Pentostatin + Tofacitinib
Gravidade: Grave
Pentostatin and Tofacitinib: major interaction.
Última atualização
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
O conteúdo clínico desta página está disponível apenas em inglês.
Resumo
Pentostatin causes profound lymphocyte depletion and immunosuppression, so combining it with tofacitinib increases the risk of severe and opportunistic infections. Pentostatin also has other toxicities such as renal and neurologic effects.
O que esta interação significa em palavras simples
Pentostatin and Tofacitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Pentostatin belongs to Oncology; Tofacitinib belongs to Musculoskeletal.
Por que acontece
Additive immunosuppression from JAK inhibition and adenosine deaminase inhibition causing lymphocyte toxicity.
O que fazer
Avoid concurrent use and consider holding tofacitinib during pentostatin therapy. If both are needed, monitor for infection and consider prophylaxis.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Para assinantes do Pro+
Desbloqueie a página completa
Crie uma conta e comece um teste do Pro+ para desbloquear a orientação completa de conduta para Pentostatin e Tofacitinib, as notas adicionais, os detalhes da evidência e o verificador de interações para uma prescrição completa.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Experimente o Pro+ grátis por 14 dias na web. Sem cartão.
Outras interações de Tofacitinib
- Baricitinib + Tofacitinib Contraindicada
- Cladribine + Tofacitinib Contraindicada
- Tofacitinib + Upadacitinib Contraindicada
- Abatacept + Tofacitinib Grave
- Anti-thymocyte + Tofacitinib Grave
- Antithymocyte globulin equine + Tofacitinib Grave
Outras interações de Pentostatin
- Carmustine + Pentostatin Contraindicada
- Etoposide + Pentostatin Contraindicada
- Fludarabine + Pentostatin Contraindicada
- Cyclophosphamide + Pentostatin Grave
- Deferiprone + Pentostatin Grave
- Fingolimod + Pentostatin Grave
Perguntas frequentes
Can I take Pentostatin with Tofacitinib?
MediHelp rates the interaction as major. Pentostatin and Tofacitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pentostatin causes profound lymphocyte depletion and immunosuppression, so combining it with tofacitinib increases the risk of severe and opportunistic infections. Pentostatin also has other toxicities such as renal and neurologic effects.
How serious is the interaction between Pentostatin and Tofacitinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use and consider holding tofacitinib during pentostatin therapy. If both are needed, monitor for infection and consider prophylaxis.
What other medicines interact with Tofacitinib?
MediHelp also lists interactions of Tofacitinib with, for example, Baricitinib, Cladribine, Upadacitinib. The full list is on the Tofacitinib page.
Monografias completas, posologia e verificador de interações no app MediHelp
Abra a referência completa, verifique interações entre vários medicamentos e use as ferramentas de posologia no app MediHelp.
