藥物交互作用
Bupropion + Deutetrabenazine
嚴重程度: 嚴重
Bupropion and Deutetrabenazine: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Bupropion is a strong CYP2D6 inhibitor and markedly raises exposure to the active metabolites of deutetrabenazine. This increases the risk of sedation, akathisia, parkinsonism, depression and QT prolongation.
用白話說明這項交互作用的意義
Bupropion and Deutetrabenazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Bupropion belongs to Central Nervous System; Deutetrabenazine belongs to Central Nervous System.
為什麼會發生
Bupropion inhibits CYP2D6, reducing clearance of deutetrabenazine's active dihydro-metabolites.
處置方式
Limit deutetrabenazine to no more than 18 mg per dose and 36 mg per day while bupropion is used. Monitor for adverse effects such as depression, somnolence and QT prolongation.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Bupropion 的其他交互作用
Deutetrabenazine 的其他交互作用
常見問題
Can I take Bupropion with Deutetrabenazine?
MediHelp rates the interaction as major. Bupropion and Deutetrabenazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Bupropion is a strong CYP2D6 inhibitor and markedly raises exposure to the active metabolites of deutetrabenazine. This increases the risk of sedation, akathisia, parkinsonism, depression and QT prolongation.
How serious is the interaction between Bupropion and Deutetrabenazine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit deutetrabenazine to no more than 18 mg per dose and 36 mg per day while bupropion is used. Monitor for adverse effects such as depression, somnolence and QT prolongation.
What other medicines interact with Bupropion?
MediHelp also lists interactions of Bupropion with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Bupropion page.
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