藥物交互作用
Deutetrabenazine + Valbenazine
嚴重程度: 禁忌併用
Deutetrabenazine and Valbenazine: contraindicated interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Both drugs are VMAT2 inhibitors, so combining them provides duplicate therapy and increases the risk of adverse effects such as sedation, depression, parkinsonism and QT prolongation. There is no rationale for using the two together.
用白話說明這項交互作用的意義
Deutetrabenazine and Valbenazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Deutetrabenazine belongs to Central Nervous System; Valbenazine belongs to Central Nervous System.
為什麼會發生
Duplicate VMAT2 inhibition causes additive pharmacodynamic effects and excessive monoamine depletion.
處置方式
Do not use together; choose one VMAT2 inhibitor. Allow adequate washout when switching between agents.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Deutetrabenazine 的其他交互作用
Valbenazine 的其他交互作用
常見問題
Can I take Deutetrabenazine with Valbenazine?
MediHelp rates the interaction as contraindicated. Deutetrabenazine and Valbenazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both drugs are VMAT2 inhibitors, so combining them provides duplicate therapy and increases the risk of adverse effects such as sedation, depression, parkinsonism and QT prolongation. There is no rationale for using the two together.
How serious is the interaction between Deutetrabenazine and Valbenazine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together; choose one VMAT2 inhibitor. Allow adequate washout when switching between agents.
What other medicines interact with Deutetrabenazine?
MediHelp also lists interactions of Deutetrabenazine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Deutetrabenazine page.
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