藥品參考
Tislelizumab
Tislelizumab is a medicine in the class oncology. It is used for gastric cancer.
- 藥物類別: Oncology
- 用途: gastric cancer
最後更新 來源: EMA SmPC
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本頁的臨床內容僅提供英文版。
重點資訊
- 藥物類別
- Oncology
- ATC 代碼
- L01FF09
- 常見劑型
- 注射劑
- 常見規格
- 10 mg/ml
- 已知交互作用
- 6 (中度: 5 · 輕微: 1)
- 商品名
- 2
- 國家與市場
- 2
用途
作用方式
Humanised IgG4 variant monoclonal antibody against PD-1 that binds the extracellular domain of human PD-1 and competitively blocks binding of PD-L1 and PD-L2. This inhibits PD-1-mediated negative signalling and enhances T-cell functional activity in in vitro assays.
成人常用劑量（仿單摘要）
Monotherapy: 200 mg once every 3 weeks or 400 mg once every 6 weeks, intravenous infusion; treat until disease progression or unacceptable toxicity
懷孕與哺乳
- 懷孕
- Unsafe No data in pregnant women; can cause foetal harm based on its mechanism of action. Do not use during pregnancy unless the woman's clinical condition requires treatment.
- 哺乳
- Unsafe Unknown whether excreted in human milk; women should not breast-feed during treatment and for at least 4 months after the last dose.
已通報的副作用
- Anaemia
- Aspartate aminotransferase increased
- Fatigue
- Alanine aminotransferase increased
- Neutropenia (with chemotherapy)
- Thrombocytopenia (with chemotherapy)
禁忌症
- Hypersensitivity to the active substance or to any excipient.
哪些人需要特別留意
- Immune-related adverse reactions, including fatal cases, can affect any organ system and may occur after the last dose; evaluate and withhold, with corticosteroids as needed.
- Immune-related pneumonitis, including fatal cases; monitor for signs and symptoms.
- Immune-related hepatitis; perform liver function tests at baseline and periodically.
請告知藥師或醫師您是否懷孕或哺乳、是否患有腎臟或肝臟疾病、是否有過敏，以及您正在使用的所有其他藥物或保健品。
重要交互作用 (6)
- Amoxicillin + Tislelizumab Moderate
- Amoxicillin-clavulanic acid + Tislelizumab Moderate
- Piperacillin + Tislelizumab Moderate
- Piperacillin-tazobactam + Tislelizumab Moderate
- Prednisone + Tislelizumab Moderate
- Penicillin g + Tislelizumab Minor
同類別的其他藥品
常見問題
What is Tislelizumab used for?
Tislelizumab is a medicine in the class oncology. It is used for Gastric cancer, Lung cancer, Non-small cell lung cancer, Squamous cell carcinoma.
What side effects have been reported with Tislelizumab?
Anaemia, Aspartate aminotransferase increased, Fatigue, Alanine aminotransferase increased, Neutropenia (with chemotherapy), Thrombocytopenia (with chemotherapy).
Can Tislelizumab be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. No data in pregnant women; can cause foetal harm based on its mechanism of action. Do not use during pregnancy unless the woman's clinical condition requires treatment. Breastfeeding: Unsafe. Unknown whether excreted in human milk; women should not breast-feed during treatment and for at least 4 months after the last dose.
What does Tislelizumab interact with?
MediHelp lists 6 known interactions for Tislelizumab. Moderate: 5 · Minor: 1. The most serious include Amoxicillin, Amoxicillin-clavulanic acid, Piperacillin.
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