藥物交互作用
Amitriptyline + Guanfacine
嚴重程度: 中度
Amitriptyline and Guanfacine: moderate interaction.
最後更新
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
摘要
Tricyclics may blunt the antihypertensive effect of centrally acting alpha-2 agonists. Both drugs also cause sedation and may cause orthostatic hypotension or bradycardia.
用白話說明這項交互作用的意義
Amitriptyline and Guanfacine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amitriptyline belongs to Central Nervous System; Guanfacine belongs to Cardiovascular.
為什麼會發生
Tricyclics may antagonize alpha-2 agonist action, and there is additive sedative and hypotensive pharmacodynamic effect.
處置方式
Monitor blood pressure and heart rate and adjust guanfacine as required. Monitor for sedation and dizziness.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Amitriptyline 的其他交互作用
Guanfacine 的其他交互作用
常見問題
Can I take Amitriptyline with Guanfacine?
MediHelp rates the interaction as moderate. Amitriptyline and Guanfacine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tricyclics may blunt the antihypertensive effect of centrally acting alpha-2 agonists. Both drugs also cause sedation and may cause orthostatic hypotension or bradycardia.
How serious is the interaction between Amitriptyline and Guanfacine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate and adjust guanfacine as required. Monitor for sedation and dizziness.
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
