藥物交互作用
Guanfacine + Lofexidine
嚴重程度: 嚴重
Guanfacine and Lofexidine: major interaction.
最後更新
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
摘要
Both drugs are central alpha-2 adrenergic agonists that lower blood pressure and heart rate. Taking them together duplicates therapy and can cause marked hypotension, bradycardia, sedation and syncope.
用白話說明這項交互作用的意義
Guanfacine and Lofexidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Guanfacine belongs to Cardiovascular; Lofexidine belongs to Central Nervous System.
為什麼會發生
Duplicate central alpha-2 agonism producing additive sympatholytic, hypotensive and bradycardic effects.
處置方式
Avoid concurrent use where possible and choose one alpha-2 agonist. If both are required, monitor blood pressure and heart rate closely and reduce doses as needed.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Lofexidine 的其他交互作用
Guanfacine 的其他交互作用
常見問題
Can I take Guanfacine with Lofexidine?
MediHelp rates the interaction as major. Guanfacine and Lofexidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs are central alpha-2 adrenergic agonists that lower blood pressure and heart rate. Taking them together duplicates therapy and can cause marked hypotension, bradycardia, sedation and syncope.
How serious is the interaction between Guanfacine and Lofexidine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use where possible and choose one alpha-2 agonist. If both are required, monitor blood pressure and heart rate closely and reduce doses as needed.
What other medicines interact with Lofexidine?
MediHelp also lists interactions of Lofexidine with, for example, Adagrasib, Alfuzosin, Amiodarone. The full list is on the Lofexidine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
