藥物交互作用
Amiodarone + Guanfacine
嚴重程度: 中度
Amiodarone and Guanfacine: moderate interaction.
最後更新
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摘要
Amiodarone may increase guanfacine concentrations, and both agents can slow the heart rate and lower blood pressure. This increases the risk of bradycardia, hypotension and sedation.
用白話說明這項交互作用的意義
Amiodarone and Guanfacine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amiodarone belongs to Cardiovascular; Guanfacine belongs to Cardiovascular.
為什麼會發生
CYP3A4 inhibition by amiodarone raising guanfacine levels, with additive bradycardic and hypotensive effects.
處置方式
Reduce extended-release guanfacine to half the usual dose as labeled and monitor heart rate and blood pressure. Titrate on tolerability.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Amiodarone 的其他交互作用
Guanfacine 的其他交互作用
常見問題
Can I take Amiodarone with Guanfacine?
MediHelp rates the interaction as moderate. Amiodarone and Guanfacine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amiodarone may increase guanfacine concentrations, and both agents can slow the heart rate and lower blood pressure. This increases the risk of bradycardia, hypotension and sedation.
How serious is the interaction between Amiodarone and Guanfacine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce extended-release guanfacine to half the usual dose as labeled and monitor heart rate and blood pressure. Titrate on tolerability.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
