藥物交互作用
Amlodipine-benazepril + Carbidopa
嚴重程度: 中度
Amlodipine-benazepril and Carbidopa: moderate interaction.
最後更新
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摘要
Carbidopa, usually given with levodopa, increases dopamine formation outside the brain and can enhance the blood pressure lowering of antihypertensives. Orthostatic hypotension and dizziness may become more pronounced, especially when levodopa therapy is started or increased.
用白話說明這項交互作用的意義
Amlodipine-benazepril and Carbidopa can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-benazepril belongs to Cardiovascular; Carbidopa belongs to Central Nervous System.
為什麼會發生
Additive pharmacodynamic hypotensive effect from peripheral dopaminergic activity of levodopa combined with vasodilation and ACE inhibition.
處置方式
Monitor supine and standing blood pressure when carbidopa-levodopa is started or titrated. Reduce the antihypertensive dose if symptomatic hypotension occurs.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Amlodipine-benazepril 的其他交互作用
Carbidopa 的其他交互作用
常見問題
Can I take Amlodipine-benazepril with Carbidopa?
MediHelp rates the interaction as moderate. Amlodipine-benazepril and Carbidopa can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbidopa, usually given with levodopa, increases dopamine formation outside the brain and can enhance the blood pressure lowering of antihypertensives. Orthostatic hypotension and dizziness may become more pronounced, especially when levodopa therapy is started or increased.
How serious is the interaction between Amlodipine-benazepril and Carbidopa?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor supine and standing blood pressure when carbidopa-levodopa is started or titrated. Reduce the antihypertensive dose if symptomatic hypotension occurs.
What other medicines interact with Amlodipine-benazepril?
MediHelp also lists interactions of Amlodipine-benazepril with, for example, Aliskiren, Sacubitril / valsartan, Aldesleukin. The full list is on the Amlodipine-benazepril page.
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