藥物交互作用
Amlodipine-perindopril + Carbidopa
嚴重程度: 中度
Amlodipine-perindopril and Carbidopa: moderate interaction.
最後更新
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摘要
Carbidopa is given with levodopa, and levodopa can cause orthostatic hypotension that adds to the effects of antihypertensives. Patients on amlodipine and perindopril may have more pronounced blood pressure falls when levodopa-carbidopa is started or increased.
用白話說明這項交互作用的意義
Amlodipine-perindopril and Carbidopa can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-perindopril belongs to Cardiovascular; Carbidopa belongs to Central Nervous System.
為什麼會發生
Additive hypotension, as levodopa formed in the presence of carbidopa adds to the vasodilatory and ACE-inhibitor effects.
處置方式
Monitor standing and sitting blood pressure when starting or adjusting levodopa-carbidopa. Reduce the antihypertensive dose if symptomatic hypotension occurs.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Amlodipine-perindopril 的其他交互作用
Carbidopa 的其他交互作用
常見問題
Can I take Amlodipine-perindopril with Carbidopa?
MediHelp rates the interaction as moderate. Amlodipine-perindopril and Carbidopa can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbidopa is given with levodopa, and levodopa can cause orthostatic hypotension that adds to the effects of antihypertensives. Patients on amlodipine and perindopril may have more pronounced blood pressure falls when levodopa-carbidopa is started or increased.
How serious is the interaction between Amlodipine-perindopril and Carbidopa?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor standing and sitting blood pressure when starting or adjusting levodopa-carbidopa. Reduce the antihypertensive dose if symptomatic hypotension occurs.
What other medicines interact with Amlodipine-perindopril?
MediHelp also lists interactions of Amlodipine-perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Amlodipine-perindopril page.
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