藥物交互作用
Amphotericin b deoxycholate + Magnesium
嚴重程度: 中度
Amphotericin b deoxycholate and Magnesium: moderate interaction.
最後更新
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摘要
Amphotericin B deoxycholate causes renal tubular injury that leads to urinary magnesium wasting and hypomagnesemia. Low magnesium can aggravate hypokalemia and predispose to arrhythmias, particularly in patients receiving prolonged therapy.
用白話說明這項交互作用的意義
Amphotericin b deoxycholate and Magnesium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
為什麼會發生
Amphotericin B damages the renal tubules and increases urinary excretion of magnesium and potassium.
處置方式
Monitor serum magnesium and potassium regularly during amphotericin B therapy. Replace magnesium as needed to correct deficits.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Magnesium 的其他交互作用
常見問題
Can I take Amphotericin b deoxycholate with Magnesium?
MediHelp rates the interaction as moderate. Amphotericin b deoxycholate and Magnesium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amphotericin B deoxycholate causes renal tubular injury that leads to urinary magnesium wasting and hypomagnesemia. Low magnesium can aggravate hypokalemia and predispose to arrhythmias, particularly in patients receiving prolonged therapy.
How serious is the interaction between Amphotericin b deoxycholate and Magnesium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum magnesium and potassium regularly during amphotericin B therapy. Replace magnesium as needed to correct deficits.
What other medicines interact with Magnesium?
MediHelp also lists interactions of Magnesium with, for example, Ciprofloxacin, Pancuronium, Rocuronium. The full list is on the Magnesium page.
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