藥物交互作用
Magnesium + Rocuronium
嚴重程度: 嚴重
Magnesium and Rocuronium: major interaction.
最後更新
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
摘要
Parenteral magnesium sulfate potentiates rocuronium, shortening onset and lengthening duration of neuromuscular block. This raises the risk of delayed recovery and residual paralysis.
用白話說明這項交互作用的意義
Magnesium and Rocuronium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Magnesium belongs to Gastrointestinal Tract; Rocuronium belongs to Musculoskeletal.
為什麼會發生
Magnesium inhibits presynaptic acetylcholine release and reduces end-plate sensitivity, adding to nondepolarizing blockade.
處置方式
Use reduced rocuronium doses and monitor neuromuscular function with train-of-four. Confirm adequate reversal before extubation.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Magnesium 的其他交互作用
Rocuronium 的其他交互作用
常見問題
Can I take Magnesium with Rocuronium?
MediHelp rates the interaction as major. Magnesium and Rocuronium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Parenteral magnesium sulfate potentiates rocuronium, shortening onset and lengthening duration of neuromuscular block. This raises the risk of delayed recovery and residual paralysis.
How serious is the interaction between Magnesium and Rocuronium?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use reduced rocuronium doses and monitor neuromuscular function with train-of-four. Confirm adequate reversal before extubation.
What other medicines interact with Magnesium?
MediHelp also lists interactions of Magnesium with, for example, Ciprofloxacin, Pancuronium, Vecuronium. The full list is on the Magnesium page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
