藥物交互作用
Magnesium + Pancuronium
嚴重程度: 嚴重
Magnesium and Pancuronium: major interaction.
最後更新
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摘要
Parenteral magnesium sulfate enhances and prolongs neuromuscular blockade from pancuronium. Recovery can be delayed and postoperative respiratory weakness may occur.
用白話說明這項交互作用的意義
Magnesium and Pancuronium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Magnesium belongs to Gastrointestinal Tract; Pancuronium belongs to Musculoskeletal.
為什麼會發生
Magnesium reduces presynaptic acetylcholine release and decreases postsynaptic sensitivity, adding to nondepolarizing blockade.
處置方式
Reduce the neuromuscular blocker dose and monitor with quantitative train-of-four. Ensure full reversal before extubation in patients receiving magnesium.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Magnesium 的其他交互作用
Pancuronium 的其他交互作用
常見問題
Can I take Magnesium with Pancuronium?
MediHelp rates the interaction as major. Magnesium and Pancuronium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Parenteral magnesium sulfate enhances and prolongs neuromuscular blockade from pancuronium. Recovery can be delayed and postoperative respiratory weakness may occur.
How serious is the interaction between Magnesium and Pancuronium?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the neuromuscular blocker dose and monitor with quantitative train-of-four. Ensure full reversal before extubation in patients receiving magnesium.
What other medicines interact with Magnesium?
MediHelp also lists interactions of Magnesium with, for example, Ciprofloxacin, Rocuronium, Vecuronium. The full list is on the Magnesium page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
