藥物交互作用
Atracurium + Magnesium
嚴重程度: 中度
Atracurium and Magnesium: moderate interaction.
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摘要
Parenteral magnesium sulfate potentiates and prolongs neuromuscular blockade from atracurium. This may lead to delayed recovery and prolonged respiratory muscle weakness.
用白話說明這項交互作用的意義
Atracurium and Magnesium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atracurium belongs to Musculoskeletal; Magnesium belongs to Gastrointestinal Tract.
為什麼會發生
Magnesium reduces presynaptic acetylcholine release and lowers postsynaptic sensitivity, adding to nondepolarizing blockade.
處置方式
Reduce neuromuscular blocker dose and monitor with train-of-four. Be prepared for prolonged ventilatory support.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Magnesium 的其他交互作用
Atracurium 的其他交互作用
常見問題
Can I take Atracurium with Magnesium?
MediHelp rates the interaction as moderate. Atracurium and Magnesium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Parenteral magnesium sulfate potentiates and prolongs neuromuscular blockade from atracurium. This may lead to delayed recovery and prolonged respiratory muscle weakness.
How serious is the interaction between Atracurium and Magnesium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce neuromuscular blocker dose and monitor with train-of-four. Be prepared for prolonged ventilatory support.
What other medicines interact with Magnesium?
MediHelp also lists interactions of Magnesium with, for example, Ciprofloxacin, Pancuronium, Rocuronium. The full list is on the Magnesium page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
