藥物交互作用
Apalutamide + Cobimetinib
嚴重程度: 嚴重
Apalutamide and Cobimetinib: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Apalutamide may substantially reduce cobimetinib exposure, which may compromise antitumor efficacy. Cobimetinib labeling advises avoiding moderate and strong CYP3A inducers.
用白話說明這項交互作用的意義
Apalutamide and Cobimetinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Apalutamide belongs to Endocrine; Cobimetinib belongs to Oncology.
為什麼會發生
Induction of CYP3A4 increases cobimetinib metabolism.
處置方式
Avoid the combination and choose an alternative. If it cannot be avoided, monitor tumor response closely.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Apalutamide 的其他交互作用
Cobimetinib 的其他交互作用
常見問題
Can I take Apalutamide with Cobimetinib?
MediHelp rates the interaction as major. Apalutamide and Cobimetinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Apalutamide may substantially reduce cobimetinib exposure, which may compromise antitumor efficacy. Cobimetinib labeling advises avoiding moderate and strong CYP3A inducers.
How serious is the interaction between Apalutamide and Cobimetinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose an alternative. If it cannot be avoided, monitor tumor response closely.
What other medicines interact with Apalutamide?
MediHelp also lists interactions of Apalutamide with, for example, Cabotegravir, Cobicistat, Doravirine. The full list is on the Apalutamide page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
