藥物交互作用
Bosentan + Cobimetinib
嚴重程度: 嚴重
Bosentan and Cobimetinib: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Bosentan, a moderate CYP3A4 inducer, may markedly reduce cobimetinib exposure and thus its anticancer activity.
用白話說明這項交互作用的意義
Bosentan and Cobimetinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Bosentan belongs to Miscellaneous; Cobimetinib belongs to Oncology.
為什麼會發生
CYP3A4 induction by bosentan increases cobimetinib clearance.
處置方式
Avoid coadministration; use an alternative to bosentan or consider a different therapy, and monitor tumor response if unavoidable.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Bosentan 的其他交互作用
Cobimetinib 的其他交互作用
常見問題
Can I take Bosentan with Cobimetinib?
MediHelp rates the interaction as major. Bosentan and Cobimetinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Bosentan, a moderate CYP3A4 inducer, may markedly reduce cobimetinib exposure and thus its anticancer activity.
How serious is the interaction between Bosentan and Cobimetinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid coadministration; use an alternative to bosentan or consider a different therapy, and monitor tumor response if unavoidable.
What other medicines interact with Bosentan?
MediHelp also lists interactions of Bosentan with, for example, Cyclosporin, Cyclosporine, Glyburide. The full list is on the Bosentan page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
