藥物交互作用
Apalutamide + Tofacitinib
嚴重程度: 嚴重
Apalutamide and Tofacitinib: major interaction.
最後更新
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
摘要
Apalutamide is a strong inducer of CYP3A4 and CYP2C19, the enzymes that clear tofacitinib. Exposure to tofacitinib may fall and its therapeutic effect may be reduced.
用白話說明這項交互作用的意義
Apalutamide and Tofacitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Apalutamide belongs to Endocrine; Tofacitinib belongs to Musculoskeletal.
為什麼會發生
Induction of CYP3A4 and CYP2C19 increases the metabolism of tofacitinib.
處置方式
Avoid the combination where possible and choose an alternative. If it cannot be avoided, monitor for loss of tofacitinib efficacy and adjust therapy accordingly.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Tofacitinib 的其他交互作用
Apalutamide 的其他交互作用
常見問題
Can I take Apalutamide with Tofacitinib?
MediHelp rates the interaction as major. Apalutamide and Tofacitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Apalutamide is a strong inducer of CYP3A4 and CYP2C19, the enzymes that clear tofacitinib. Exposure to tofacitinib may fall and its therapeutic effect may be reduced.
How serious is the interaction between Apalutamide and Tofacitinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible and choose an alternative. If it cannot be avoided, monitor for loss of tofacitinib efficacy and adjust therapy accordingly.
What other medicines interact with Tofacitinib?
MediHelp also lists interactions of Tofacitinib with, for example, Baricitinib, Cladribine, Upadacitinib. The full list is on the Tofacitinib page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
