藥物交互作用
Apalutamide + Valbenazine
嚴重程度: 嚴重
Apalutamide and Valbenazine: major interaction.
最後更新
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摘要
Apalutamide may substantially lower exposure to valbenazine and its active metabolite. This may reduce control of tardive dyskinesia.
用白話說明這項交互作用的意義
Apalutamide and Valbenazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Apalutamide belongs to Endocrine; Valbenazine belongs to Central Nervous System.
為什麼會發生
Apalutamide induces CYP3A4, which metabolizes valbenazine and its active metabolite.
處置方式
Avoid concomitant use, as valbenazine labeling advises against strong CYP3A4 inducers. Consider an alternative treatment if apalutamide is required.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Apalutamide 的其他交互作用
Valbenazine 的其他交互作用
常見問題
Can I take Apalutamide with Valbenazine?
MediHelp rates the interaction as major. Apalutamide and Valbenazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Apalutamide may substantially lower exposure to valbenazine and its active metabolite. This may reduce control of tardive dyskinesia.
How serious is the interaction between Apalutamide and Valbenazine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concomitant use, as valbenazine labeling advises against strong CYP3A4 inducers. Consider an alternative treatment if apalutamide is required.
What other medicines interact with Apalutamide?
MediHelp also lists interactions of Apalutamide with, for example, Cabotegravir, Cobicistat, Doravirine. The full list is on the Apalutamide page.
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