藥物交互作用
Tranylcypromine + Valbenazine
嚴重程度: 禁忌併用
Tranylcypromine and Valbenazine: contraindicated interaction.
最後更新
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摘要
Valbenazine is a VMAT2 inhibitor that depletes monoamines, and MAOIs raise synaptic monoamine levels. The combination may reduce valbenazine efficacy and may increase the risk of serotonin toxicity. Labeling contraindicates concomitant use with MAOIs.
用白話說明這項交互作用的意義
Tranylcypromine and Valbenazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Tranylcypromine belongs to Central Nervous System; Valbenazine belongs to Central Nervous System.
為什麼會發生
Opposing effects on monoamine disposition: VMAT2 inhibition versus MAO inhibition preventing monoamine breakdown.
處置方式
Do not combine; select an alternative therapy. Observe the washout period recommended in the labeling when changing between agents.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Tranylcypromine 的其他交互作用
Valbenazine 的其他交互作用
常見問題
Can I take Tranylcypromine with Valbenazine?
MediHelp rates the interaction as contraindicated. Tranylcypromine and Valbenazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Valbenazine is a VMAT2 inhibitor that depletes monoamines, and MAOIs raise synaptic monoamine levels. The combination may reduce valbenazine efficacy and may increase the risk of serotonin toxicity. Labeling contraindicates concomitant use with MAOIs.
How serious is the interaction between Tranylcypromine and Valbenazine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; select an alternative therapy. Observe the washout period recommended in the labeling when changing between agents.
What other medicines interact with Tranylcypromine?
MediHelp also lists interactions of Tranylcypromine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Tranylcypromine page.
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