藥物交互作用
Atazanavir + Nizatidine
嚴重程度: 嚴重
Atazanavir and Nizatidine: major interaction.
最後更新
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摘要
Atazanavir needs an acidic stomach for dissolution, and nizatidine raises gastric pH. This can substantially lower atazanavir levels and risk virologic failure and resistance.
用白話說明這項交互作用的意義
Atazanavir and Nizatidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Atazanavir belongs to Anti Virals; Nizatidine belongs to Gastrointestinal Tract.
為什麼會發生
Nizatidine raises gastric pH, reducing the pH-dependent solubility and absorption of atazanavir.
處置方式
Give atazanavir with or at least 10 hours after the H2 blocker, and use ritonavir boosting at the labeled doses; avoid in treatment-experienced patients unless labeled adjustments are followed.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Nizatidine 的其他交互作用
Atazanavir 的其他交互作用
常見問題
Can I take Atazanavir with Nizatidine?
MediHelp rates the interaction as major. Atazanavir and Nizatidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Atazanavir needs an acidic stomach for dissolution, and nizatidine raises gastric pH. This can substantially lower atazanavir levels and risk virologic failure and resistance.
How serious is the interaction between Atazanavir and Nizatidine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give atazanavir with or at least 10 hours after the H2 blocker, and use ritonavir boosting at the labeled doses; avoid in treatment-experienced patients unless labeled adjustments are followed.
What other medicines interact with Nizatidine?
MediHelp also lists interactions of Nizatidine with, for example, Dasatinib, Erlotinib, Itraconazole. The full list is on the Nizatidine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
