藥物交互作用
Nizatidine + Rilpivirine
嚴重程度: 嚴重
Nizatidine and Rilpivirine: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Rilpivirine needs an acidic stomach for adequate absorption, and nizatidine raises gastric pH. Lower rilpivirine levels may lead to virologic failure and development of resistance.
用白話說明這項交互作用的意義
Nizatidine and Rilpivirine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Nizatidine belongs to Gastrointestinal Tract; Rilpivirine belongs to Anti Virals.
為什麼會發生
Elevated gastric pH reduces the solubility and absorption of rilpivirine.
處置方式
Take nizatidine at least 12 hours before or at least 4 hours after rilpivirine. Monitor HIV viral load.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Nizatidine 的其他交互作用
Rilpivirine 的其他交互作用
常見問題
Can I take Nizatidine with Rilpivirine?
MediHelp rates the interaction as major. Nizatidine and Rilpivirine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Rilpivirine needs an acidic stomach for adequate absorption, and nizatidine raises gastric pH. Lower rilpivirine levels may lead to virologic failure and development of resistance.
How serious is the interaction between Nizatidine and Rilpivirine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Take nizatidine at least 12 hours before or at least 4 hours after rilpivirine. Monitor HIV viral load.
What other medicines interact with Nizatidine?
MediHelp also lists interactions of Nizatidine with, for example, Atazanavir, Dasatinib, Erlotinib. The full list is on the Nizatidine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
