藥物交互作用
Dasatinib + Nizatidine
嚴重程度: 嚴重
Dasatinib and Nizatidine: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Dasatinib absorption depends on an acidic gastric environment, and H2 blockers raise gastric pH. Exposure to dasatinib may fall, risking reduced antileukemic efficacy.
用白話說明這項交互作用的意義
Dasatinib and Nizatidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dasatinib belongs to Oncology; Nizatidine belongs to Gastrointestinal Tract.
為什麼會發生
Reduced pH-dependent dissolution and absorption of dasatinib due to gastric acid suppression.
處置方式
Avoid H2 blockers with dasatinib; use short-acting antacids instead, given about 2 hours before or after dasatinib.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Nizatidine 的其他交互作用
Dasatinib 的其他交互作用
常見問題
Can I take Dasatinib with Nizatidine?
MediHelp rates the interaction as major. Dasatinib and Nizatidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dasatinib absorption depends on an acidic gastric environment, and H2 blockers raise gastric pH. Exposure to dasatinib may fall, risking reduced antileukemic efficacy.
How serious is the interaction between Dasatinib and Nizatidine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid H2 blockers with dasatinib; use short-acting antacids instead, given about 2 hours before or after dasatinib.
What other medicines interact with Nizatidine?
MediHelp also lists interactions of Nizatidine with, for example, Atazanavir, Erlotinib, Itraconazole. The full list is on the Nizatidine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
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