藥物交互作用
Ketoconazole + Nizatidine
嚴重程度: 嚴重
Ketoconazole and Nizatidine: major interaction.
最後更新
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摘要
Ketoconazole requires an acidic stomach for dissolution and absorption. Nizatidine can substantially reduce ketoconazole exposure and lead to antifungal failure.
用白話說明這項交互作用的意義
Ketoconazole and Nizatidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ketoconazole belongs to Anti Fungals; Nizatidine belongs to Gastrointestinal Tract.
為什麼會發生
Elevated gastric pH decreases dissolution and absorption of ketoconazole.
處置方式
Avoid the combination where possible, or use an alternative antifungal. If unavoidable, give ketoconazole at least 2 hours before nizatidine.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Nizatidine 的其他交互作用
Ketoconazole 的其他交互作用
常見問題
Can I take Ketoconazole with Nizatidine?
MediHelp rates the interaction as major. Ketoconazole and Nizatidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ketoconazole requires an acidic stomach for dissolution and absorption. Nizatidine can substantially reduce ketoconazole exposure and lead to antifungal failure.
How serious is the interaction between Ketoconazole and Nizatidine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, or use an alternative antifungal. If unavoidable, give ketoconazole at least 2 hours before nizatidine.
What other medicines interact with Nizatidine?
MediHelp also lists interactions of Nizatidine with, for example, Atazanavir, Dasatinib, Erlotinib. The full list is on the Nizatidine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
