藥物交互作用
Atidarsagene autotemcel + Raltegravir
嚴重程度: 嚴重
Atidarsagene autotemcel and Raltegravir: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Antiretroviral drugs can interfere with the manufacture of this lentiviral gene therapy by inhibiting transduction of mobilized cells. Raltegravir, an integrase inhibitor, may reduce the efficiency of vector integration.
用白話說明這項交互作用的意義
Atidarsagene autotemcel and Raltegravir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Atidarsagene autotemcel belongs to Miscellaneous; Raltegravir belongs to Anti Virals.
為什麼會發生
Antiretrovirals inhibit lentiviral vector transduction of harvested stem cells during manufacturing.
處置方式
Stop raltegravir at least one month before mobilization, or longer to cover drug elimination, and keep it off through apheresis. Arrange alternative HIV management with the treating team.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Raltegravir 的其他交互作用
Atidarsagene autotemcel 的其他交互作用
常見問題
Can I take Atidarsagene autotemcel with Raltegravir?
MediHelp rates the interaction as major. Atidarsagene autotemcel and Raltegravir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Antiretroviral drugs can interfere with the manufacture of this lentiviral gene therapy by inhibiting transduction of mobilized cells. Raltegravir, an integrase inhibitor, may reduce the efficiency of vector integration.
How serious is the interaction between Atidarsagene autotemcel and Raltegravir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Stop raltegravir at least one month before mobilization, or longer to cover drug elimination, and keep it off through apheresis. Arrange alternative HIV management with the treating team.
What other medicines interact with Raltegravir?
MediHelp also lists interactions of Raltegravir with, for example, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Aluminum hydroxide / magnesium carbonate, Aluminum hydroxide / magnesium trisilicate. The full list is on the Raltegravir page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
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