藥物交互作用
Atracurium + Betamethasone
嚴重程度: 中度
Atracurium and Betamethasone: moderate interaction.
最後更新
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摘要
Corticosteroids given with non-depolarizing neuromuscular blockers, particularly during prolonged ICU use, have been associated with acute quadriplegic myopathy and prolonged muscle weakness. This can delay recovery and weaning from ventilation.
用白話說明這項交互作用的意義
Atracurium and Betamethasone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atracurium belongs to Musculoskeletal; Betamethasone belongs to Endocrine.
為什麼會發生
Combined effects on muscle fiber integrity and neuromuscular function leading to myopathy; the exact mechanism is not fully established.
處置方式
Keep the duration of neuromuscular blockade and steroid exposure as short as possible and monitor neuromuscular function. Assess for persistent weakness and consider creatine kinase if myopathy is suspected.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Atracurium 的其他交互作用
Betamethasone 的其他交互作用
常見問題
Can I take Atracurium with Betamethasone?
MediHelp rates the interaction as moderate. Atracurium and Betamethasone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticosteroids given with non-depolarizing neuromuscular blockers, particularly during prolonged ICU use, have been associated with acute quadriplegic myopathy and prolonged muscle weakness. This can delay recovery and weaning from ventilation.
How serious is the interaction between Atracurium and Betamethasone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Keep the duration of neuromuscular blockade and steroid exposure as short as possible and monitor neuromuscular function. Assess for persistent weakness and consider creatine kinase if myopathy is suspected.
What other medicines interact with Atracurium?
MediHelp also lists interactions of Atracurium with, for example, Amikacin, Bacitracin-neomycin-polymyxin, Benzhydrocodone / acetaminophen. The full list is on the Atracurium page.
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