藥物交互作用
Avatrombopag + Phenytoin
嚴重程度: 中度
Avatrombopag and Phenytoin: moderate interaction.
最後更新
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
摘要
Phenytoin induces CYP2C9 and CYP3A4, both of which metabolise avatrombopag. Platelet response to avatrombopag may be reduced.
用白話說明這項交互作用的意義
Avatrombopag and Phenytoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Avatrombopag belongs to Miscellaneous; Phenytoin belongs to Central Nervous System.
為什麼會發生
Phenytoin induces CYP2C9 and CYP3A4, accelerating avatrombopag clearance.
處置方式
In ITP, use the higher avatrombopag starting dose recommended in labeling for dual inducers. Monitor platelet counts and adjust the dose accordingly.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Phenytoin 的其他交互作用
Avatrombopag 的其他交互作用
常見問題
Can I take Avatrombopag with Phenytoin?
MediHelp rates the interaction as moderate. Avatrombopag and Phenytoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phenytoin induces CYP2C9 and CYP3A4, both of which metabolise avatrombopag. Platelet response to avatrombopag may be reduced.
How serious is the interaction between Avatrombopag and Phenytoin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: In ITP, use the higher avatrombopag starting dose recommended in labeling for dual inducers. Monitor platelet counts and adjust the dose accordingly.
What other medicines interact with Phenytoin?
MediHelp also lists interactions of Phenytoin with, for example, Artemether / lumefantrine, Bictegravir, Cabotegravir. The full list is on the Phenytoin page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
